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One center was withdrawn from the study after it had enrolled 12 patients for failure to comply with the treatment assignments, because 5 patients in the intravenous t-PA group had been treated with intravenous t-PA followed by endovascular treatment (3 patients) or directly with endovascular therapy (2 patients), and 1 patient in the endovascular-treatment group had been given intravenous t-PA. To determine whether data from this center could have biased the final result, we did a post hoc sensitivity analysis on the primary outcome, excluding these 12 patients, all of whom had a poor outcome (modified Rankin score, 2 to 6), and found that the overall result was not affected (adjusted odds ratio, 0.71; 95% CI, 0.43 to 1.14; P=0.16).